Paracetamol-Induced Splenic Toxicity and the Protective Role of Vitamin C in Albino Rats

Ahlaam M. Khalid; Eda M.A. Alshailabi; Ola A. Abdalally

doi:10.33214/pyyfqc31

Authors

Ahlaam M. Khalid Higher Institute of Medical Sciences and Technology, Laboratory Department, El-Beyda, Libya. Author
Eda M.A. Alshailabi Omar Al-Mukhtar University, Zoology Department, Faculty of Science, El-Beyda, Libya Author
Ola A. Abdalally Almahara institute for the medical and managerial sciences, El-Beyda, Libya. Author

DOI:

https://doi.org/10.33214/pyyfqc31

Keywords:

Paracetamol, Spleen, Vitamin C, Albino rats, Histopathology.

Abstract

Paracetamol (PCM) is widely used as an analgesic and antipyretic agent; however, overdose can result in systemic toxicity, primarily mediated through oxidative stress. This study aimed to evaluate the histopathological effects of PCM on the spleen of albino rats and to assess the potential protective effect of vitamin C (VC) as an antioxidant. Twenty-eight albino rats were randomly assigned to five groups: control, VC (500 mg/kg), PCM (500 mg/kg), PCM + VC co-treatment, and a prophylactic group receiving VC before PCM administration. Histological examination of the spleen revealed alterations in the PCM-only group, including lymphoid depletion in the white pulp and congestion in the red pulp. Co-administration of VC attenuated these changes, while pre-treatment with VC provided the greatest preservation of splenic architecture. These findings suggest a potential protective benefit of VC against PCM-induced oxidative damage in the spleen

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Published

2026-02-02

Issue

Vol. 2 No. 1 (2026)

Section

Original Articles

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This work is licensed under a Creative Commons Attribution 4.0 International License.

How to Cite

M. Khalid, A., M.A. Alshailabi , E., & A. Abdalally, O. (2026). Paracetamol-Induced Splenic Toxicity and the Protective Role of Vitamin C in Albino Rats. Libyan Journal of Life Sciences, 2(1), 13-19. https://doi.org/10.33214/pyyfqc31